4 Best Anti-Aging Injections to Keep Your Skin Looking Young and Slow the Process of Aging

Tired of creams that don’t deliver and procedures that cost a fortune? When it comes to reversing visible signs of aging like wrinkles, sagging, or dullness, anti-aging injections offer real, science-backed results without surgery.

In this guide, we’ll show you the four most effective injections that go beyond surface-level fixes. From collagen-stimulating peptides to wrinkle-smoothing neurotoxins and volume-restoring fillers, you’ll learn which treatments work best for different skin concerns, how long results last, and how to get started safely.

Let’s break down exactly how these injectables work, and which one may be best for your goals.

Anti-Aging Injections and Their Role in Skin Rejuvenation

Anti-aging injections work in different ways. Some boost your body’s natural repair systems, while others smooth wrinkles or restore volume. The most common types include:

• Longevity & cellular support (e.g., Sermorelin, NAD+, Glutathione): These help your body repair itself from the inside out, improving energy, skin texture, and slowing signs of aging.
  
• Wrinkle relaxers (e.g., Botox, Dysport): These relax facial muscles to reduce lines and wrinkles, especially around the eyes and forehead.
  
• Dermal fillers (e.g., Juvederm, Restylane): Fillers add volume to areas like the cheeks or lips, helping lift sagging skin and smooth out deeper lines.

4 Anti-Aging Injections For Long-Term Skin Health and Longevity

Want better skin and lasting energy? These four anti-aging injections work from within. Each supports skin, metabolism, and cell repair in different ways. Here's how they help.

1. Sermorelin

Sermorelin is an anti-aging peptide therapy that boosts your body’s natural growth hormone levels. It supports smoother, firmer skin by enhancing collagen production, improving sleep, and increasing fat metabolism. Over time, it helps restore skin elasticity and slow visible signs of aging. Our guide helps you understand how Sermorelin compares to traditional HGH therapy.

2. NAD+

NAD+ is a vital coenzyme that fuels your cells’ energy production and repair processes. It helps reduce inflammation, smooth skin tone, and support mitochondrial function. Regular use promotes a healthier, more radiant complexion and can slow age-related decline from the inside out.

3. Glutathione

Glutathione is a master antioxidant that helps detox your body and brighten the skin. It protects against environmental stressors, reduces pigmentation, and supports even skin tone. Many users see clearer, more luminous skin with consistent use, making it a popular choice for an enhanced glow and anti-aging.

4. Lipotropic (MIC) + B12

The Lipotropic (MIC) + B12 injection blends vitamin B12 with amino acids that support fat metabolism and cellular energy. It enhances mood, supports detox pathways, and promotes clearer, healthier skin by aiding cell renewal. A great option for those seeking both metabolic and cosmetic benefits.

Wrinkle-Relaxing Injectables for Expression Lines

Expression lines like crow’s feet and forehead wrinkles, are caused by repetitive muscle movement. Neurotoxin injectables temporarily relax those muscles, smoothing the overlying skin.

Botox

Botox is the most well-known wrinkle relaxer. It targets dynamic lines by blocking nerve signals to overactive facial muscles. Most people see results within 3–5 days, with effects lasting 3–4 months. It’s FDA-approved for forehead lines, frown lines, and crow’s feet.

Dysport

Dysport works similarly to Botox but spreads slightly more, making it ideal for larger treatment areas like the forehead. It kicks in faster, often within 2–3 days, and lasts 3–4 months. Some users find it feels more “natural” due to its diffusion pattern.

Xeomin

Xeomin is a purified form of botulinum toxin without accessory proteins. This makes it less likely to trigger resistance over time. It works similarly to Botox, with results in 3–4 days and a similar duration. It's a popular pick for those switching from other toxins.

Comparison Table: Botox vs. Dysport vs. Xeomin

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Dermal Fillers That Restore Volume and Contour

As we age, the face loses volume and collagen, leading to sagging and hollowed areas. Dermal fillers can help rebuild youthful contours and restore plumpness.

Juvederm

Juvederm is a hyaluronic acid-based filler used to plump lips, fill smile lines, and restore cheek volume. Its smooth gel texture creates natural-looking results with minimal swelling. Results typically last 9–18 months depending on the treatment area and product formulation.

Restylane

Restylane also uses hyaluronic acid but has a firmer consistency, making it ideal for sculpting the jawline, lifting cheeks, or smoothing deep folds. It blends well with natural tissue and lasts around 6–12 months, depending on the specific product used.

Radiesse

Radiesse is made from calcium hydroxylapatite microspheres and works by stimulating collagen production. It’s best for deeper lines, facial volume restoration, and even hand rejuvenation. Results can last 12–24 months, with ongoing improvement from collagen remodeling.

Comparison Table: Popular Dermal Fillers

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Where Anti-Aging Injections Are Most Effective

Certain areas of the face and body respond best to injectables. Here’s where you’ll see the most visible improvements:

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Forehead and Eye Area

Botox and Dysport reduce crow’s feet, frown lines, and forehead creases, creating a smoother, more refreshed appearance. In a clinical trial, onabotulinumtoxinA (Botox) led to visible wrinkle reduction in over 66% of patients at both rest and maximum smile, compared to just 7% in the placebo group.

Cheeks and Jawline

Fillers and NAD+ injections help lift sagging cheeks and sculpt the jawline for a firmer facial profile.

Pro Tip: Combine wrinkle relaxers with fillers or NAD+ for a full-face rejuvenation strategy.

Under-Eyes and Tear Troughs

Hollowing or dark circles under the eyes can make you look tired even when well-rested. Carefully placed hyaluronic acid fillers restore lost volume and brighten the under-eye area, minimizing shadowing and puffiness with natural-looking results.

Lips and Perioral Lines

Loss of collagen and repetitive movement often lead to thinning lips and fine lines around the mouth. Lip fillers such as Juvederm or Restylane enhance volume and smooth vertical lines, while a small dose of Botox can relax a gummy smile or lip flip.

Neck and Décolletage

Fine lines and crepey skin on the neck and chest respond well to Botox, skin boosters, or collagen stimulators. These treatments improve skin texture, elasticity, and tone in areas often overlooked but prone to aging, and their effectiveness is supported by clinical research.

What to Expect Before, During, and After Treatment

Initial Consultation

You’ll begin with a consultation where your provider reviews your skin concerns, goals, and medical history. Based on this, they’ll recommend the right combination of injectables and tailor a treatment plan specifically for you.

Custom Treatment Planning

No one-size-fits-all protocols here. Your provider will select the most suitable injection types, dosage, and schedule, whether you’re focused on wrinkle reduction, skin volume, or long-term cellular health.

Injection Day

The treatment itself is quick, usually 15–30 minutes. Your provider may apply numbing cream or ice. Most injections involve little discomfort and zero downtime, and you can return to normal activities right away.

Immediate Aftercare

You might notice mild swelling, redness, or sensitivity at the injection site, which fades within hours or days. Avoid alcohol, heavy workouts, and direct sun exposure for 24 hours to allow optimal healing.

Results and Maintenance

Depending on the injection type, results can appear in days or build gradually over weeks. Wrinkle relaxers may last 3–4 months, fillers up to 18 months, and wellness peptides require ongoing cycles for full benefit.

Who Benefits Most from Anti-Aging Injections?

Preventative Users (Ages 25–35)

Younger adults turn to injectables to prevent fine lines from forming. Treatments like light Botox and NAD+ help preserve collagen, support skin firmness, and slow early signs of aging before they become noticeable.

Visible Aging Phase (Ages 35–50)

At this stage, wrinkles, volume loss, and uneven tone become more visible. Candidates benefit from a combination of wrinkle relaxers, dermal fillers, and peptides like Sermorelin to restore structure and glow.

Mature Skin Restoration (50+)

Those with more advanced aging see the best results from multi-layered treatment plans. Dermal fillers can lift sagging areas, while NAD+ and Glutathione improve energy, skin texture, and cellular repair from within.

High-Stress or Burnout Recovery

People recovering from chronic stress, travel, or poor sleep often experience dull skin and fatigue. NAD+ injections and B12 support cellular energy, improve recovery, and bring back radiance quickly.

Post-Weight Loss or Hormonal Changes

Significant weight loss or menopause can accelerate skin aging. Candidates in this group benefit from injectables that rebuild volume (fillers) and support hormonal balance and skin elasticity (like Sermorelin or Glutathione).

Safety, Side Effects, and Considerations

Mild Swelling and Redness

Common with fillers and neurotoxins, slight swelling or redness at the injection site is normal and typically fades within hours to a few days. 

Tip: Apply a cold compress and avoid heat or strenuous activity to help reduce any inflammation.

Bruising or Tenderness

Some patients may experience light bruising or tenderness where the needle enters the skin, especially in areas with thinner skin or dense capillaries. This is temporary and usually resolves without treatment.

Allergic Reactions (Rare)

Though rare, some injectables, especially those derived from proteins or peptides, may cause allergic responses like itching, rash, or mild swelling. Always disclose any history of allergies to your provider beforehand.

Overcorrection or Asymmetry

Incorrect placement or dosage of dermal fillers or wrinkle relaxers can lead to uneven results. This underscores the importance of working with licensed, experienced injectors who understand facial anatomy.

Hormonal Sensitivity with Peptide Injections

Injections like Sermorelin may influence hormone pathways. While beneficial for most, some may experience mild water retention, fatigue, or changes in appetite. These effects are typically dose-dependent and fade with adjustments. 

For more detail, you can refer to our guide on sermorelin side effects.

Similarly, you can experience mild and transient NAD+ injection side effects like nausea, flushing, or headache, particularly if you administer it too quickly.

Enhancing Results with Skincare and Lifestyle

Anti-aging injections deliver powerful results, but your daily habits determine how long those results last. For maximum impact, pair your treatments with a consistent skincare routine that includes moisturizers, SPF, and retinoids. This can help

Prioritize internal support too: NAD+ and Glutathione help defend against oxidative stress, while hydration, sleep, and stress reduction keep skin firm and glowing. You can supplement these between cycles with options like NAD+ nasal spray for added convenience.

Think of injectables as the foundation, and lifestyle as the upkeep. Together, they work to maintain smoother skin, better tone, and a more youthful appearance over time.

Alternatives to Anti-Aging Injections

Not everyone is ready for injectables, and that’s okay. These non-invasive therapies support healthy aging from the inside out, and can be used alone or alongside injections for enhanced results.

NAD+ Nasal Spray

This needle-free spray supports cellular energy, mental focus, and long-term vitality. It’s a convenient way to raise NAD+ levels daily, ideal for those looking to maintain youthful function without injections.

BPC-157

BPC-157 is a healing peptide that promotes recovery, reduces inflammation, and supports joint, gut, and muscle health. It’s often used alongside aesthetic treatments to help the body repair from the inside out.

Metformin

Popular in longevity circles, Metformin may improve insulin sensitivity, mitochondrial function, and cellular repair. It’s often used in anti-aging and weight loss protocols to help extend healthspan and support metabolic balance.

NMN

Nicotinamide Mononucleotide (NMN) is a NAD+ precursor shown to enhance energy production, cognitive performance, and skin elasticity over time. It’s an excellent add-on for those not ready for NAD+ injections.

Cost and Longevity of Different Injections

Prices and results vary widely among injectables. Here's a comparison to help you choose the best fit based on budget and desired longevity:

Injection Cost & Longevity Guide

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Why Consider IVY RX?

IVY RX takes a clinically guided approach to aging support, offering prescription injectables you can administer from home, no clinic visits required. Each plan is designed for safety, consistency, and convenience.

• Transparent monthly pricing starting at $199
  
• Includes telehealth consultations and medical oversight
  
• Lab tracking and dose personalization tailored to your goals
  
• Home delivery of medication, syringes, and support materials
  
• Flexible plans that fit different budgets and timelines

For individuals looking to maintain skin health and overall vitality, IVY RX offers a streamlined, evidence-based way to stay on track.

Begin Your Anti-Aging Journey with IvyRx

You don’t need to wait for visible signs of aging to start protecting your skin and supporting your body from within. Whether you’re focused on wrinkle prevention, restoring skin vitality, or boosting overall energy, IVY RX offers medically guided, at-home treatments to help you stay ahead.

Ready to take the next step? Explore our personalized anti-aging plans and read more about how to increase NAD+ levels naturally to support skin health and longevity.

References

• Carruthers, A., Bruce, S., De Coninck, A., Connolly, S., Cox, S. E., Davis, P. G., Campo, A., Lei, X., Somogyi, C., Lee, E., McLean, H., & Beddingfield, F. (2014). Efficacy and safety of OnabotulinumtoxinA for the treatment of crow's feet lines. Dermatologic Surgery, 40(11), 1181–1190. https://doi.org/10.1097/dss.0000000000000128
• Rho, N.-K., Kim, H.-S., Kim, S.-Y., & Lee, W. (2024, November 13). Injectable “skin boosters” in aging skin rejuvenation: A current overview. Archives of Plastic Surgery, 51(6), 528–541. https://doi.org/10.1055/a-2366-3436

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