5 Best Peptides for Weight Loss: Top Options for 2025

Most times, when metabolism slows or hunger feels nonstop, traditional methods can fall short. 

However, using peptides for weight loss offers a targeted boost to help you burn stubborn fat and maintain steady energy.

In this guide, we’ll cover how each of the top 5 weight-loss peptides works, who benefits most, typical costs, and key safety tips, so you can choose the right peptide and begin your weight-loss journey. 

Understanding Peptides and Their Role in Weight Management

Peptides are short chains of amino acids that send signals to your body, telling it when you’re full, how to break down fat, and how to use insulin more effectively — use insulin to break down blood sugar levels in the body.

For weight loss, Sermorelin stimulates your pituitary gland to release more growth hormone for enhanced fat-burning.

NAD⁺ injections boost cellular energy and metabolic rate. MIC B12 lipotropic shots support liver detoxification and accelerate fat breakdown.

Glutathione aids antioxidant defenses and improves insulin sensitivity, and Metformin helps regulate blood sugar and enhance GLP-1 activity. 

When prescribed and monitored by a healthcare professional, these peptide and peptide-adjacent therapies become a targeted, science-backed toolkit to kick-start your progress and keep it on track.

Let’s see the 5 best peptides for weight loss with more details:

Peptide #1 Sermorelin

Sermorelin is a synthetic peptide that mimics your body’s natural growth hormone-releasing hormone (GHRH), triggering regular pulses of growth hormone. 

By boosting GH release, it enhances fat metabolism, supports lean muscle growth, and promotes sustainable weight management, while also improving sleep quality and energy levels under medical supervision

Benefits

• Preserves and builds lean muscle
• Increases metabolic rate
• Targets visceral fat
• Supports energy and recovery

Potential Side Effects

• Injection site redness or swelling
• Headache, dizziness, flushing
• Joint or muscle discomfort

You can learn more in our in-depth guide on sermorelin side effects.

Who It Works Best For

Adults 35+ with age-related collagen decline seek injectable peptides for anti-aging.

Pricing

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You can also read our in-depth comparison of Sermorelin vs. HGH to find the right therapy for your wellness goals.

Peptide #2: NAD+ (Nicotinamide Adenine Dinucleotide)

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NAD⁺ (nicotinamide adenine dinucleotide) is a vital coenzyme that converts nutrients into cellular energy and activates enzymes involved in metabolism. 

As NAD⁺ levels decline with age, your cells’ ability to burn fat and regulate blood sugar diminishes. 

Restoring NAD⁺ supports mitochondrial function, boosts metabolic rate, and helps maintain a healthy weight.

Benefits

• Enhances fat-burning and energy
• Supports cellular repair and anti-aging
• May improve insulin sensitivity

Potential Side Effects

• Nausea, headache, flushing
• Dizziness, mild muscle pain

Who It Works Best For

Best for individuals seeking metabolic optimization and energy support.

Learn how NAD⁺ can support your weight-loss journey in our more in-depth guide.

Pricing

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Peptide#3: MIC B12 (Lipotropic Injections)

‍MIC + B12 (Lipotropic Injections) combines methionine, inositol, and choline, nutrients that support liver function and fat breakdown, with vitamin B12 to enhance cellular energy. 

By improving your liver’s ability to process fats and supplying an energy boost, these injections help you burn stubborn body fat more efficiently and sustain workouts.

Benefits

• Supports fat metabolism and liver health
• Boosts energy and mood
• May reduce appetite and cravings
• Enhances exercise performance

Potential Side Effects

• Mild injection site discomfort
• Nausea, muscle cramps, swelling

Who It Works Best For

People seeking an energy boost and metabolic support alongside diet and exercise.

Pricing

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Peptide#4: Glutathione

Glutathione is a key antioxidant peptide composed of three amino acids that support liver detoxification and reduce oxidative stress. 

By clearing toxins and improving insulin sensitivity, glutathione injections help your body access stored fat for energy more efficiently, enhancing the effects of diet and exercise for steady weight loss.

Benefits

• Reduces oxidative stress and inflammation
• May support fat metabolism and insulin sensitivity
• Promotes detoxification and cellular health

Potential Side Effects

• Injection site discomfort, nausea, headache
• Rare: allergic reactions, diarrhea, zinc deficiency

Who It Works Best For

Individuals seeking antioxidant support and metabolic health as part of a broader wellness plan.

Pricing

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Read our comparison of Glutathione vs. NAD if you’re still unsure about which peptide would be best for your health goals.

Peptide#5: Metformin

Metformin is an oral prescription medication that isn’t a peptide but enhances levels of natural GLP-1, supporting appetite control and improving insulin sensitivity. 

By helping your body regulate blood sugar and energy use, metformin complements peptide therapies to promote gradual, sustainable fat loss when paired with diet and exercise.

Benefits

• Modest weight loss (1–5% of body weight)
• Improves insulin sensitivity and blood sugar
• May suppress appetite and reduce fat storage
• Reduces hunger for lower calorie intake and weight loss

Potential Side Effects

• Nausea, diarrhea, abdominal discomfort
• Rare: vitamin B12 deficiency, lactic acidosis

Who It Works Best For

People with insulin resistance, prediabetes, or type 2 diabetes are seeking gradual weight loss and metabolic improvement.

Pricing

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Comparing Peptides for Weight Loss Effectiveness

Here’s a standard table comparing the best 5 peptides for weight loss:

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You can also see our detailed comparison guide on Sermorelin vs Tesamorelin.

Risks, Side Effects, and Safety Considerations

While peptides for weight loss and metabolic support can be highly effective, they may incur certain health risks and side effects. Different peptides may have different side effects. 

Here are some general side effects to expect, though bear in mind that these will not be applicable to every peptide:

Gastrointestinal Disturbances

Many weight-loss peptides (especially GLP-1s like semaglutide and metformin) commonly cause nausea, vomiting, diarrhea, or bloating. 

These symptoms typically ease over the first few weeks but may require dose adjustments or supportive measures (e.g., smaller meals, hydration) if they persist or worsen.

Injection Site Reactions & Allergies

Any injectable peptide can trigger redness, swelling, itching, or mild pain at the injection site. However, rotating injection sites, using a sterile technique, and sourcing your treatment from a reputable provider help minimize these risks.

Headaches, Dizziness & Fatigue

Some users report headaches, dizziness, or transient fatigue when starting peptide therapy, likely reflecting shifts in blood sugar or blood pressure. 

These effects often resolve within days to weeks. Staying well-hydrated, monitoring vital signs, and communicating with your clinician can help manage discomfort.

Rare but Serious Events

Though uncommon, certain weight-loss peptides have been linked to more severe issues:

• Pancreatitis (with GLP-1 agonists)
• Gallbladder disease or biliary sludge
• Thyroid C-cell changes (animal data)
• Hypoglycemia, especially if combined with other glucose-lowering drugs

Note: Always consult a healthcare provider, like Ivy Rx, to monitor side effects and adjust treatment as needed.

Oral vs Injectable Peptides for Weight Loss

Choosing between injectable and oral peptides for weight loss comes down to balancing potency, convenience, and cost. 

Injectable options, like semaglutide, tirzepatide, sermorelin, and NAD⁺, deliver active compounds directly into your bloodstream for faster, more reliable fat-burning and appetite control, but require medical supervision and can be pricier. 

Meanwhile, oral therapies like metformin or lipotropic capsules are easier to take and often less expensive, yet their absorption is highly variable, and results tend to be more modest.

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Begin your weight loss journey with expert oversight and home delivery by exploring IvyRx’s peptide therapies.

Ideal Candidates for Effective Peptide Treatment

• Prediabetes/Type 2 Diabetes: Benefit most from GLP-1s (semaglutide, tirzepatide) and metformin.
• Age-Related Metabolic Decline: Sermorelin and NAD⁺ support decreasing hormone and energy levels.
• Weight-Loss Plateau: MIC + B12 lipotropic and glutathione help overcome stubborn fat.

Access Trusted Peptide Treatments

For safety and results, always use medically supervised, prescription-grade peptides for fat loss. Avoid “research-grade” or unregulated sources. 

Telehealth platforms like IvyRx connect you with licensed providers, personalized protocols, and ongoing support, ensuring you get the right peptide injections for weight loss, safely and conveniently.

Explore IvyRx’s peptide options.

Start Your Peptide Journey With IVYRx Today

IVYRx offers science-backed, physician-guided peptide therapies, including GLP-1s, Sermorelin, NAD+, MIC B12, Glutathione, and Metformin, tailored to your unique needs. 

Book a consultation, get a personalized plan, and start seeing real results. Take the next step toward a healthier, more confident you.

Start your weight loss journey with IVYRx.

References

1. Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. https://pubmed.ncbi.nlm.nih.gov/18031173/. DOI: 10.2165/00063030-199912020-00007. 

2. Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. https://pubmed.ncbi.nlm.nih.gov/18031173/. DOI: 10.2165/00063030-199912020-00007.

3. Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2022 Oct 1;150(4 Suppl ):41S-48S. https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/. doi: 10.1097/PRS.0000000000009673. 

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