6 Best Contrave Alternatives for Weight Loss in 2025

Whether you're experiencing side effects, not seeing the results you want, or simply looking for the best contrave alternatives, there are various options.

Contrave (naltrexone/bupropion) is an FDA-approved prescription medication that produces clinically significant weight loss when combined with diet and exercise. However, a significant proportion of patients experience adverse effects, leading many to seek alternatives.

In this guide, we will explore six proven Contrave alternatives that may better align with your weight loss goals, medical needs, and budget.

6 Alternatives To Contrave

Here are six evidence-based alternatives that work through different mechanisms than Contrave's appetite suppression approach.

Personalized GLP-1 Injections

GLP-1 medications are contrave alternatives that offer various approaches to weight loss through injectable treatments. These medications include semaglutide (found in Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound), which work by mimicking hormones that regulate blood sugar and slow gastric emptying.

GLP-1 Injections (Semaglutide & Tirzepatide) Pros

• Clinically proven weight loss: Studies show users can lose between 15–22.5% of their body weight with consistent use, diet, and exercise.
• Metabolic benefits: Both medications improve blood sugar regulation, support insulin sensitivity, and may reduce the risk of type 2 diabetes.
• Appetite control: They help reduce hunger signals and cravings, making it easier to stay in a calorie deficit.
• Once-weekly dosing: A convenient injection schedule that fits most lifestyles.
• FDA-approved access: Semaglutide (Wegovy) is approved for weight loss, while Tirzepatide (Zepbound) continues to gain coverage for the same indication.
• Proven safety profile: FDA-approved for patients with a BMI of 30 or a BMI of 27 with weight-related health problems.

GLP-1 Injections (Semaglutide & Tirzepatide) Cons

• High retail cost: Without insurance, monthly fees can exceed $1,300–$1,600, making them less accessible through traditional pharmacies.
• Insurance limitations: Tirzepatide (Zepbound) is still gaining approval for weight loss, so coverage may be restricted to diabetes treatment in some cases.
• Possible side effects: Users may experience nausea, digestive discomfort, or food aversion, especially during dose escalation.
• Varied appetite response: While both suppress hunger, some users report reduced appetite control or slower results depending on dosage and individual response.

User Results and Reviews

Real-world results demonstrate significant outcomes from using GLP-1 weight-loss injections:

One semaglutide user shared, on Reddit, that her doctor prescribed the medication in May to address prediabetes, high cortisol levels, and persistent inflammation. Starting at 148 lbs (5’5”), she lost 30 pounds within the first 10 weeks, dropping to 118 lbs by July. As of her most recent update, she’s maintaining a weight of between 116 and 118lbs — reporting noticeable improvements in both body function and overall health.

The Before and After Result:

Clinical trials show average weight loss of 15-20% of total body weight with GLP-1 medications, substantially higher than the 5-10% typically seen with Contrave.

Pro tip: Start with the lowest effective dose to minimize side effects while your body adjusts to the medication.

Pricing

Here’s a pricing table for GLP-1 (Semaglutide and Tirzepatide) weight loss injections.

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Who This Alternative Is Best For

• Individuals seeking maximum weight loss: Those who need to lose significant weight and haven't achieved goals with other medications
• People with diabetes or prediabetes: GLP-1 medications provide dual benefits for blood sugar control and weight management
• Patients comfortable with injections: Those willing to self-administer weekly shots for better results

If you are ready to explore a personalized GLP-1 treatment, Ivy RX offers comprehensive consultations to determine if GLP-1’s are right for your weight loss and health goals to provide access to the treatment.

Metformin

Metformin is a low-cost diabetes medication known for supporting weight loss and metabolic health. It’s also gaining attention for metformin benefits for skin, such as reduced acne and inflammation linked to improved insulin sensitivity.

Metformin Pros

• Affordable and accessible: Generic versions cost significantly less than branded weight loss medications.
• Multiple health benefits: Improves insulin sensitivity, reduces inflammation, and may have anti-aging properties.
• Extensive safety data: Decades of clinical use with a well-understood side effect profile.
• No controlled substance restrictions: Unlike some weight loss medications, metformin isn't a controlled substance.

Metformin Cons

• Modest weight loss: Results are typically more gradual compared to GLP-1 medications.
• Gastrointestinal adjustment period: Initial nausea and digestive issues are common but usually resolve.
• Requires consistent dosing: Daily medication compliance is essential for effectiveness.
• Not suitable for everyone: Contraindicated in certain kidney and liver conditions.

User Results and Reviews

A Reddit user shared how she lost weight, although she encountered 2 months of side effects:
“I've lost about 45 lbs so far on metformin. I had some side effects on and off for about 2 months, but I'm OK now.”

Pricing

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Who This Alternative Is Best For

• Budget-conscious individuals: Those seeking adequate weight loss support without high monthly costs.
• People with insulin resistance or PCOS: Metformin improves insulin sensitivity and helps regulate hormones, making it effective for weight loss in those with PCOS or metabolic dysfunction.
• Patient preferences for oral medication: those who want to avoid injections or complex dosing schedules.

Sermorelin

Sermorelin is a growth hormone-releasing hormone (GHRH) that stimulates natural growth hormone production. This approach supports weight loss by enhancing metabolism and preserving lean muscle mass during weight reduction.

Sermorelin Pros

• Natural hormone optimization: Sermorelin helps stimulate your body's own growth hormone production rather than replacing it.
• Muscle preservation: It maintains lean muscle mass while losing fat.
• Improved sleep quality: Many users report better sleep patterns and recovery.
• Anti-aging benefits: May enhance the quality of skin, energy levels, and overall vitality.

Sermorelin Cons

• Requires daily injections: Subcutaneous administration is needed for consistent results.
• Slower onset: Benefits like fat loss and improved sleep develop gradually over months.
• Varied results: Individual responses can differ based on age, health, and hormone levels.
• Possible side effects: Some users experience injection site irritation, flushing, dizziness, or mild headaches.
• Limited insurance support: Most plans don’t cover sermorelin when used for weight loss or anti-aging.

User Results and Reviews

Here’s a testimonial from a fitness expert on Instagram, the Resistance Barbell Club, sharing the experience after 37 days using Sermorelin peptide:

“Day 37 of being on Sermorelin Peptide. So far, I have only had positive results. Visually, it seems as though I have lost some subcutaneous fat. That’s the fat just below my skin. I seem to be seeing more muscle striation, and generally, I’m feeling a greater sense of well-being. That’s probably because I’m sleeping better. This peptide causes your body to naturally release more growth hormone, which has many benefits for tissue repair, improved skin elasticity, and mental clarity.”

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Pricing

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Who This Alternative Is Best For

• Fitness enthusiasts who aim to lose fat while maintaining or building muscle.
• Patients with poor sleep quality who would benefit from improved recovery and rest.

Tired of waiting weeks for clinic appointments? Start your sermorelin evaluation with IvyRx today and get connected with licensed providers within 24 hours.

MIC + B12

MIC B12 injections combine methionine, inositol, choline, and vitamin B12 to support your fat metabolism and energy production. This combination targets lipid metabolism at the cellular level.

Pros

• Multiple mechanisms: Addresses fat metabolism, energy production, and liver function simultaneously.
• Energy enhancement: B12 component provides immediate energy benefits for many users.
• Liver support: Helps optimize liver function for better fat processing.
• Minimal side effects: Generally well-tolerated with few adverse reactions.

Cons

• Injection requirement: Weekly or bi-weekly injections needed for sustained benefits.
• Supporting role: Works best as part of a comprehensive weight loss program.
• Individual response: Some patients experience significant benefits, while others see minimal changes.
• Not a standalone solution: Requires commitment to diet and exercise for optimal results.

User Results and Reviews

Users frequently report increased energy levels within the first week, with gradual improvements in weight loss when combined with proper diet and exercise. Results are typically more subtle than prescription medications but sustainable.

Pricing

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Who This Alternative Is Best For

• People seeking metabolic support: Those who want to enhance their body's natural fat-burning processes.
• Individuals with low energy: Patients experiencing fatigue that interferes with weight loss efforts.
• Complement to other treatments: Those using it alongside other weight loss strategies.

MIC + B12 injections can enhance your weight loss journey by supporting healthy fat metabolism and energy levels. Learn more about our personalized injection protocols.

NAD+

NAD+ (nicotinamide adenine dinucleotide) plays a crucial role in cellular energy production and metabolism. Supplementation may support weight loss by optimizing cellular function and metabolic efficiency.

Pros

• Cellular energy optimization: Directly supports mitochondrial function and energy production.
• Potential longevity benefits: May support healthy aging processes and cellular repair.
• Metabolic enhancement: Helps optimize various metabolic pathways.
• Multiple delivery options: Available as injections or nasal sprays.

Cons

• Emerging research: Long-term weight loss benefits are still being studied.
• Cost consideration: More expensive than traditional weight loss supplements.
• Variable individual response: Results can vary significantly between patients.
• Limited insurance coverage: Rarely covered by insurance for weight loss purposes.

User Results and Reviews

Early users report improvements in energy levels and overall well-being, with some experiencing enhanced weight loss when combined with proper diet and exercise. Research into weight-specific benefits continues to develop.

Pricing

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Who This Alternative Is Best For

• People with chronic fatigue: Individuals whose energy levels interfere with weight loss efforts
• Patients seeking cellular health support: Those wanting comprehensive metabolic optimization

Glutathione

Glutathione is a powerful antioxidant that supports cellular detoxification and may aid weight loss by reducing inflammation and supporting liver function.

Pros

• Antioxidant powerhouse: Helps combat oxidative stress that can interfere with metabolism.
• Liver support: Optimizes liver function for better fat processing and detoxification.
• Inflammation reduction: May help address chronic inflammation that impedes weight loss.
• Skin and overall health benefits: Users often report improved skin quality and general well-being.

Cons

• Supporting role: Best used as part of a comprehensive approach rather than a standalone treatment.
• Gradual effects: Benefits typically develop slowly over time.
• Variable absorption: Effectiveness can depend on individual factors and delivery method.
• Research limitations: Weight-specific benefits need more extensive study

User Results and Reviews

Users typically report improved energy, better skin quality, and enhanced overall well-being. Weight loss benefits are generally subtle but may support other weight loss efforts.

Pricing

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Who This Alternative Is Best For

• Individuals with high oxidative stress: Those whose inflammatory burden may interfere with weight loss
• People seeking comprehensive health support: Patients wanting benefits beyond weight loss alone
• Those with liver concerns: Individuals who would benefit from enhanced detoxification support

Factors to Consider When Choosing a Contrave Alternative

Selecting the right alternative requires careful consideration of multiple factors that affect both effectiveness and sustainability.

Medical History and Current Health Conditions

Your existing diagnoses shape what’s safe and effective. For example, GLP-1 medications or metformin may be better suited if you have type 2 diabetes. At the same time, metabolic therapies like sermorelin could be more appropriate for those with thyroid concerns or hormonal imbalances.

Why it matters: Certain medications can either conflict with underlying conditions or enhance treatment outcomes when used in alignment with them. Always consult your provider for a personalized recommendation.

Budget and Insurance Coverage

The actual cost of treatment goes beyond the sticker price. Some medications offer better insurance coverage or savings programs, while others — like compounded or telehealth-based options — may be cheaper out-of-pocket.

Why it matters: Cost can affect treatment consistency. Choose something sustainable, not just affordable in the short term.

Lifestyle and Convenience

Daily pills, weekly injections, or occasional therapies — each comes with different routines. If you travel often, dislike needles, or need simple scheduling, specific options may fit better than others.

Why it matters: Consistency drives results. A treatment that fits your lifestyle increases the chances of sticking with it.

Realistic Timeline Expectations

Some alternatives provide rapid results while others work gradually over months. Align your choice with your timeline expectations and patience level for seeing changes.

Support System and Monitoring Requirements

Different alternatives require varying levels of medical supervision and monitoring. Consider your access to healthcare providers and preference for hands-on medical support.

Access Affordable Contrave Alternatives Through Ivy RX

You don’t need to rely on overpriced medications or complicated insurance approvals to lose weight effectively. Ivy RX offers affordable, medically backed alternatives to Contrave, without the hassle.

From GLP-1 injections like semaglutide and tirzepatide to proven metabolic enhancers, our treatments are personalized to your body, goals, and budget. Every plan includes a licensed medical evaluation, fast delivery, and unlimited support throughout your journey.

Skip the guesswork. Start your free consultation today to find a safer, more innovative alternative to Contrave — backed by expert care and accessible pricing.

FAQs

Are Contrave alternatives safer than Contrave?

Some alternatives, like FDA-approved GLP-1s, have well-documented safety for weight loss. Others, like metabolic enhancers, may cause fewer side effects but aren’t as extensively studied. The safest option depends on your health profile; consult your provider to choose wisely.

Do Contrave alternatives work for everyone?

No. Effectiveness varies by individual. Your response depends on factors like genetics, health conditions, lifestyle, and cost or coverage. The best option is one tailored to your unique needs.

Should I talk to my doctor before switching from Contrave?

Yes, always consult with your healthcare provider before changing weight loss medications. They can help you safely transition between treatments, monitor for interactions with other medications, and ensure the new approach aligns with your overall health strategy. 

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