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NAD+ Nasal Spray Dosage Guide | Safe & Effective Use
Trying to figure out the proper NAD nasal spray dosage can be tricky. You want to make sure you’re using enough to see benefits, but not too much to risk any issues. That’s where this guide comes in.
We’ll answer your burning question; what’s the right NAD nasal spray dosage?
You’ll learn a clear, easy-to-follow breakdown of the proper dosage and how to get the most from your spray, you’ll feel confident in your usage.
Let’s walk you through all the NAD+ nasal spray dosing details to ensure you're using it effectively.
Understanding NAD+ Nasal Spray and How It Works
To truly understand NAD+ nasal spray, let’s first look at what NAD+ is.
NAD+ (Nicotinamide Adenine Dinucleotide) is a vital molecule that powers your cells, aids DNA repair, and boosts cognitive health.
Unfortunately, as we age, our NAD+ and NADH levels naturally decline, slowing down these vital processes. Unlike oral supplements, NAD+ nasal sprays deliver this coenzyme directly into your bloodstream, bypassing digestion.
The result is faster and more efficient absorption. This means more NAD+ reaches your cells quickly, giving you a boost of energy and mental clarity easily.
Recommended NAD+ Nasal Spray Dosage
When using NAD+ nasal spray, the correct dosage depends on your needs and the specific product.
Beginner Dosage
For products with 30 mg per spray, this is a common starting point.
- Dosage: Start with 1 spray in each nostril once a day.
- Purpose: This helps your body adjust to the spray without overwhelming it.
Moderate Dosage
Some formulations recommend this for optimal results.
- Dosage: Try 1 spray in each nostril twice a day.
- Purpose: This boosts the effects if you're feeling comfortable with the lower dose.
Advanced Dosage
Higher doses may be used for specific needs like energy or recovery.
- Dosage: You can go up to 2 sprays in each nostril twice a day.
- Purpose: This is for people looking for stronger results.
Note: the dosages above are not medical advice. Please consult with your doctor or medical provider before increasing your dosing.
Here’s a quick reference chart for NAD+ nasal spray dosages based on your needs:

NAD+ Nasal Spray Benefits
By directly replenishing NAD+ levels through the nasal mucosa, NAD+ nasal spray offers key benefits described below.
Enhanced Energy Levels
NAD+ nasal spray promotes ATP production. This powers your cells and helps reduce feelings of fatigue. With regular use, you can experience increased energy, vitality, and reduced burnout, so you stay active throughout the day.
Improved Cognitive Function
By supporting brain health, NAD+ nasal spray enhances memory, focus, and mental clarity. It helps reduce brain fog and supports mental sharpness. This is particularly useful in situations that require intense focus, such as long periods of study or work.
Anti-Aging Effects
NAD+ nasal spray plays a key role in DNA repair and combats oxidative stress. This slows down the aging process by protecting cells from damage and supporting longevity. It helps maintain youthful skin and cellular health.
Faster Absorption
Unlike oral supplements, NAD+ nasal sprays deliver the coenzyme directly to the bloodstream via the nasal mucosa. It bypasses the digestive system. And this results in quicker and more efficient absorption.
Stronger Immune System
NAD+ strengthens your immune cells, improving your body’s ability to fight infections. A stronger immune system means you’re better protected against illness.
NAD+ Nasal Spray Dosage by Use Case
The right NAD+ nasal spray dosage is key to achieving your health goals while avoiding side effects. Dosage recommendations can vary based on your specific needs and the product you use.
Anti-Aging and Longevity
- Recommended dosage: 1–2 sprays per nostril, once or twice daily.
- Rationale: This dosage helps support cellular repair and mitochondrial function, potentially slowing age-related decline.
Cognitive Enhancement and Mental Clarity
- Recommended dosage: 1–2 sprays per nostril, once or twice daily.
- Rationale: Consistent dosing boosts brain cell activity, improving focus, memory, and mental clarity while reducing oxidative stress.
Athletic Performance and Recovery
- Recommended dosage: 1–2 sprays per nostril, once or twice daily, particularly before or after workouts.
- Rationale: NAD+ aids energy production and muscle recovery. Supplementing with NAD+ nasal spray can help reduce fatigue and enhance endurance.
Mood Support and Stress Management
- Recommended dosage: 1–2 sprays per nostril, once or twice daily.
- Rationale: NAD+ supports neurotransmitter function and cellular repair, potentially aiding in stress management and improving mood stability.
Note: Always consult with a healthcare professional before starting supplementation.
NAD+ Nasal Spray vs. Other Delivery Methods
When it comes to delivering NAD+ to your body, there are several options available. Each method has its benefits and drawbacks, and it’s important to choose the one that fits your needs.
IV Therapy
Absorption: 100% bioavailability; delivers NAD+ directly into the bloodstream for between 3-14 days.
- IV therapy offers the fastest, most potent NAD+ delivery, ideal for immediate effects, such as treating chronic fatigue or neurodegenerative conditions.
- It requires a clinical setting, higher costs, more frequent injections and longer administration time.
- Best for those needing rapid, high-dose replenishment, but not convenient or affordable for consistent use.
NAD+ Injections
Absorption: Direct delivery into subcutaneous (fatty) tissue, bypassing the digestive system.
- At-home NAD+ injections provide faster NAD+ absorption than oral supplements, with precise dosing.
- Ideal for those seeking more convenient and faster effects than oral supplements and are confident in administration of injections themselves with provider guidance.

Oral Supplements
Absorption: NAD+ precursors like NMN or NR are absorbed through the digestive system.
- NAD+ oral supplements compared to injections are convenient, cost-effective, and easy to use.
- However, they have limited data on effectiveness, slower absorption rates, which leads to delayed effects.
- Best for long-term maintenance but not ideal for those seeking immediate results or fast effects.
Sublingual Forms
Absorption: Direct absorption under the tongue, bypassing digestion.
- Sublingual NAD+ forms offer faster absorption than oral supplements, providing quicker effects. However, they can cause irritation under the tongue and may be less convenient for regular use compared to nasal sprays or oral supplements.
- Ideal for those seeking rapid absorption without injections.
Potential Side Effects of Incorrect NAD+ Dosage
NAD+ nasal spray can be highly effective. But incorrect dosage or improper administration may lead to some side effects. Here are a few potential issues to be aware of:
Nasal Irritation
Improper use or sensitivity can cause nasal discomfort. This may include burning or dryness in the nose. Adjusting how you use the spray in terms of technique and dosage can prevent this.
Headaches
Excessive use or too high a dosage can trigger headaches. This is more common when the dosage is too frequent. Reducing the amount or frequency can help. If headaches persist, try adjusting your routine.
Gastrointestinal Discomfort
Like NAC, some may experience mild stomach issues, like nausea or indigestion when using NAD+ nasal sprays. This can occur if the spray is absorbed systemically.
Dizziness or Lightheadedness
Rarely, dizziness or lightheadedness can occur, especially for those with underlying health conditions. Lowering the dosage or consulting a healthcare provider can help.
Fatigue
Some people may feel fatigued after using NAD+ nasal spray. This could be due to the body adjusting to increased NAD+ levels. Reducing the dosage or frequency can reduce this effect.
Using injections instead? We’ve compiled a list of potential NAD+ injection side effects.
How to Administer NAD+ Nasal Spray Safely
Follow these steps for safe and effective use of NAD+ nasal spray.
Step 1: Prepare the Spray
Shake the bottle gently to mix the solution. Prime the pump by spraying away from your face until a fine mist appears. This step ensures the spray is ready for use.
Step 2: Position Yourself
Tilt your head slightly forward to align your nasal passages. Insert the nozzle into one nostril while closing the other. This helps direct the spray to the right area.
Step 3: Administer the Spray
Press down on the pump to release the spray while inhaling gently. Repeat for the other nostril if directed. This allows even distribution of the spray.
Step 4: Aftercare
Avoid blowing your nose immediately to allow absorption. Clean the nozzle with warm water and let it air dry. Store the bottle in the refrigerator when not in use. This ensures the spray remains effective and hygienic.
Proper usage ensures optimal absorption and minimizes side effects.
Factors That Influence NAD+ Nasal Spray Dosage
Several factors can influence the ideal dosage of NAD+ nasal spray. It's important to consider these when determining the right amount for you.
Age
Younger individuals may need lower doses due to naturally higher NAD+ levels. As we age, NAD+ levels decline, so older adults often need to increase NAD+ levels to compensate for this loss.
Activity Level
Athletes or those with high physical activity may benefit from increased doses. Higher activity levels demand more energy, so boosting NAD+ can support better energy metabolism and quicker recovery.
Cognitive Goals
If your goal is to improve mental clarity, you may need a higher dosage. Enhanced cognitive function often requires more NAD+ to support brain cell activity and reduce oxidative stress.
Health Conditions
Conditions like chronic fatigue or neurodegenerative diseases may require tailored dosing. Higher or more frequent doses might be necessary to address these specific health challenges effectively.
Adjusting Your NAD+ Dosage Over Time
Monitor how your body responds to NAD+ nasal spray. If you experience reduced effects or increased fatigue, consider adjusting your dosage.
Pro Tips for Safe Dosage Adjustments
- Start with a lower dose to assess tolerance.
- Take the right dosage at the right time.
- Track any changes in your energy or side effects.
- Consult your healthcare provider regularly to adjust the dosage as needed.
- Stay consistent with your usage to maintain steady NAD+ levels.
Fast, Secure Access to NAD+ Nasal Spray with IVY RX
IVY RX makes accessing high-quality NAD+ nasal spray quick and secure. Whether you want to boost energy, enhance focus, or support healthy aging, IVY RX offers a reliable and convenient solution delivered straight to your door. Take the next step toward better health today.
Ready for the next step toward better health today? Discover IVY’s NAD+ Nasal Spray and experience the benefits for yourself.
Frequently Asked Questions
How often can I use NAD+ nasal spray?
Start with one spray per nostril daily. If tolerated, increase to two sprays once daily. Some protocols suggest twice daily, under healthcare provider guidance.
Can I combine NAD+ spray with other supplements?
Yes, NAD+ can be safely combined with supplements like GLP-1s, B12/MIC injections, and adaptogens. Always consult your healthcare provider before combining treatments.
How quickly does NAD+ nasal spray work?
Most users feel effects within an hour. Peak plasma levels occur in 15–30 minutes, offering quick benefits for enhanced cellular function.

Ivy RX patients
Members of Ivy RX branded medications were paid for their testimonials.
References:
Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2435-2448. doi: 10.1093/gerona/glad106. PMID: 37068054; PMCID: PMC10692436.
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