Metformin changed her blood sugar. This changed her life.

When Debi Gaffney stepped on the scale six months ago, she wasn’t sure anything could change. She’d already been prescribed Metformin for her blood sugar, but the weight she carried felt immovable. Exercise classes left her winded, walking the dog was a struggle, and even everyday moments with her family were shadowed by fatigue.

That’s when her care plan shifted. 

Alongside Metformin, her provider introduced a GLP-1 medication — and the results came fast. “I have lost 62 pounds in six months! I could’ve never done this without my tirzepatide and Metformin. This company has changed my life both mentally and physically. I am able to do exercise classes, walk, work, and enjoy my family and dog more than I have in the past 10 years!” Debi said.

Her story isn’t just about numbers on the scale. It’s about what happens when a proven treatment like Metformin is paired with therapies that may help extend its impact [1] — not only on weight, but on energy, clarity, and quality of life.

Why Metformin is just the beginning

Metformin has been a cornerstone of metabolic health for decades. It works by lowering the amount of sugar released by the liver and helping the body respond more effectively to insulin. For many patients, that can lead to steadier blood sugar [2], a lower risk of complications, and sometimes weight loss.

But Metformin doesn’t always address the bigger picture — fatigue, cravings, or the stubborn weight that refuses to budge. That’s where complementary treatments can make a difference.

NAD+

Take NAD+, a coenzyme found in every cell of the body. It’s central to how we produce energy at the mitochondrial level, but natural levels decline with age and metabolic stress. 

Supplementing with NAD+ can restore energy and mental clarity. Estelle Robinson described her results this way: “I used to suffer from horrible fatigue and I felt like I couldn’t make it through the day without a nap. Now I feel less sluggish, my brain fog has cleared, and my fatigue is better. Looking forward to seeing all the anti-aging effects from continuing to take NAD+.”

Cyndi Levine noticed a different benefit during her treatment: “I have more energy especially during that typical late afternoon slump. Brain fog seems to be slowly lifting, less desire for snacking on junk food, and I have lost a little weight.” Those changes are subtle but powerful — the kind of daily wins that make long-term progress sustainable.

And experts echo that potential. Dr. Brynna Connor, a physician specializing in anti-aging and regenerative medicine, told Newsweek: “Given its involvement in critical biological processes, there is the possibility that enhancing NAD+ levels could have significant implications for extending one's lifespan and improving longevity.”

Sermorelin

Other therapies aim at recovery and vitality. Sermorelin, for example, stimulates the body’s natural growth hormone production. Patients often describe deeper sleep, better workout recovery, and gradual changes in body composition. One Reddit user summed it up after several weeks: “I took it mostly to sleep better and recover from training… after some time, I felt rested better and recovered better. I believe it’s all about remaining consistent with it.”

Glutathione

And then there’s Glutathione — often called the body’s “master antioxidant.” It helps protect cells from oxidative stress, supports detoxification, and may help support the immune system [3]. For Metformin patients who want more than blood sugar control, Glutathione can be a way to invest in longer-term resilience.

Together, these therapies don’t replace Metformin — they build on it. 

Where Metformin helps manage blood sugar, add-ons can help address the parts of daily life patients actually feel [4]: the afternoon crash, the fog that makes it hard to focus, the cravings that creep in late at night, the slow recovery that leaves you dragging. When those improve, the whole journey feels different — not just manageable, but motivating.

That’s why more patients are layering in complementary treatments: because real progress isn’t just about stabilizing numbers, it’s about waking up with more energy, moving through the day with less strain, and feeling like momentum is finally on their side.

How treatments complement each other

For many patients, Metformin is the anchor — the therapy that steadies blood sugar and lays the groundwork for change. But progress doesn’t stop there. When the right therapies are layered on top, patients often describe a turning point: results that feel not only stronger, but easier to maintain.

When price is the hurdle

Cost is often the first barrier. Kimberly Jackson remembers what it felt like to hit that wall. She’d tried branded medications like Mounjaro, only to realize the price was unsustainable. With IVYrx she found another way: “The compounded meds work just as well as my more expensive Mounjaro at a fraction of the price. Check-ins with Ivy’s providers are easy and efficient, and my medications are delivered quickly and securely.” For her, pairing Metformin with a GLP-1 wasn’t just about better results — it was about finally having an option she could stick with, at a price that made sense.

When fatigue drags you down

Once that foundation is in place, the focus often shifts to energy. Fatigue and sluggishness can undermine even the best intentions. That’s where NAD+ comes in. As Chanel Sanders put it, “The NAD+ has been a game change for me.” With more energy in her day, the changes she made on Metformin began to feel less like a fight and more like a routine she could enjoy.

When it’s about more than numbers

And for many, the journey isn’t only about blood sugar or weight at all. Gains in stamina and energy often spill over into the things that motivate people most — health, confidence, and the freedom to feel good in their own skin. Wendy saw that when she added Glutathione: “I’m finding the glutathione I have been using is doing wonders for my complexion. Easy treatment for looking better and boosting my immunity.”

Together, these stories show the pattern: Metformin sets the stage, but it’s the add-ons that bring the performance to life. They turn progress from a cautious first step into something patients can feel in their bodies every day — the energy to push through the afternoon, the confidence to look in the mirror, the relief of knowing the plan is affordable enough to continue. It’s that combination that can help elevate a treatment plan from “good enough” into something truly life-changing.

From hesitation to confidence

For many people, the biggest hesitation isn’t about the treatments themselves — it’s about the process. Is it safe to do this at home? Will I get the right guidance? What happens if I have questions? 

That uncertainty shows up again and again in patient stories — and even in the voices of people who’ve shared their journeys publicly.

Learning the ropes

Rick G remembers being nervous about giving himself an injection for the first time. “I had never used an injectable before so I had questions and concerns that were all answered clearly and honestly. I’m glad I ordered from IVYrx, I highly recommend their service.”

Clear guidance at every step

That reassurance carries through the whole experience. Alia described how the medical team set her up with clear direction and everything she needed: “The doctor provided good information on dosage and safety. I was notified as the medication made its way to me and when it was delivered to my address. The medication arrived with plenty of needles and alcohol swabs and the price was reasonable which is hard to find these days.”

Feeling supported throughout

And for some, it’s not just about safety and convenience — it’s about how well-supported they feel throughout the journey. J Di summed it up this way: “IvyRX has been a game-changer for me. Their online service makes it incredibly convenient… The team is always professional, attentive, and responsive, making the entire process seamless. The treatment has significantly improved my energy levels, mental clarity, and overall well-being. I truly feel like a better version of myself.”

The message is consistent: the treatments matter, but so does the trust in how they’re delivered. For patients, knowing they’ll be guided, equipped, and supported every step of the way makes starting — and sticking with it — far easier.

But trusting the service is only part of the equation. The other is quieter and more personal: the doubts patients carry about cost, consistency, and whether they’ll really be able to stick with it. Those questions are just as real — and just as answerable.

What holds people back — and why it doesn’t have to

Even after hearing success stories, many patients hesitate. The doubts are familiar: Will I really be able to afford this? What if the results don’t last? What if I need to pause or change something along the way?

Those are perfectly natural concerns — and they’re often answered best by the people already living through the process.

Affordability in practice

For Marriane North, the first surprise was how accessible everything felt. “Love working with IVYrx. They have a fabulous customer service department and you can pretty much get ahold of someone at all times of the day. The prices are reasonable and the products seem to be effective.” Affordability and access are often the biggest barriers, and for her, they didn’t stand in the way.

Staying steady

Juliene Harrod echoed the same sense of reassurance once she settled into her routine. “Always answers my questions promptly. Received medication on time and intact. Can’t beat the price. I’m on maintenance and it’s working great!” The concern that results would fade has, for her, given way to steady progress.

Results that last

Jimmy Joe pointed to the same thing — not just results, but sustainability: “I’ve been steadily losing weight. Very reasonable pricing compared to others. Great team. Online chat works great.”

Flexibility when you need it

And for those who worry about committing to something rigid, Janae Lindberg explained the flexibility she’s found: “I can easily turn on and off automatic payments and change my credit card. I can’t think of anything I need that they don’t have. They’ve been great and I really appreciate it.”

Together, these stories show that the usual sticking points — cost, consistency, flexibility — don’t have to be dealbreakers. With the right support, patients aren’t just overcoming doubts; they’re finding reasons to stay the course.

FAQs

How do I know if I’m a candidate for these therapies?

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Eligibility starts with a brief online consultation. You’ll answer questions about your health history, current medications, and goals. A licensed provider then reviews your information to determine whether Metformin, GLP-1s, or complementary treatments like NAD+ or Glutathione are appropriate. If you qualify, a prescription is issued and a plan is tailored to your needs. If not, you’ll be advised on alternatives.

How quickly will my treatment arrive?

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Once prescribed, medications are filled by a compounding pharmacy and shipped directly to your door. Delivery usually takes between two and five business days, depending on location. Patients receive updates along the way — from processing, to shipment, to final delivery — so there are no surprises.

Is it safe to self-administer?

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Yes. Each order comes with everything you need: pre-measured vials, syringes, alcohol swabs, and step-by-step instructions. Providers walk patients through dosing during the consultation, and pharmacists are available to answer any follow-up questions. For those who prefer, some treatments are also available as nasal sprays or other non-injectable formats.

What if I experience side effects?

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Side effects vary by treatment. With Metformin, the most common are mild digestive issues that often ease after a few weeks. GLP-1s may cause nausea at the start of treatment, which is usually managed by adjusting the dose. If symptoms persist or worsen, you can message your provider directly through the online portal. Adjustments — lowering dosage, changing formulation, or pausing treatment — are built into the care plan to keep you safe.

How does cost compare with going through insurance?

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Insurance often denies coverage for GLP-1s entirely, or restricts them with complex criteria. Even when approved, co-pays can run high. IVYrx works with compounding pharmacies to offer alternatives at a fraction of the price. Patients also value the transparency — there are no hidden fees, and you know your cost upfront. Many describe it as the first time they’ve been able to plan for treatment without fear of surprise bills.

Can I pause or adjust my treatment?

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Yes. Patients have full control over their subscription, with the ability to pause shipments, change billing dates, or update payment methods. If you need to take a break for travel, surgery, or personal reasons, your plan can be adjusted. This flexibility helps people stay consistent long term, instead of worrying about wasted doses or being locked into a rigid schedule.

Ready to take the next step?

Metformin can be the start of a healthier future — but for many patients, it’s only the beginning. Adding therapies like personalized GLP-1 injections, GLP-1 Boost, NAD+ (injections and sprays), or Glutathione can close the gaps Metformin alone can’t always fill, making progress more sustainable and life noticeably better.

Theresa described what that felt like for her: “The NAD+ really helped me feel more energetic and has improved my overall health. I have been taking it for a few months now and I feel great!” 

Her story is just one example of a bigger shift patients are experiencing — where a single medication lays the foundation, and supportive treatments make the difference between coping and truly thriving.

If you’ve been managing your health with Metformin and wondering what comes next, now is the time to explore your options.

Start your consultation with IVYrx today and see how a personalized plan — from GLP-1s to NAD+ to Glutathione — can help you build on Metformin’s foundation and move toward lasting change.

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