9 Best Wegovy Alternatives for Weight Loss Support in 2025

Wegovy is a popular choice for weight loss, but it is not always the right fit for everyone. 

If you’ve been searching for the perfect Wegovy alternative, your search ends here. With so many options available, choosing the best one can be overwhelming. But don’t worry, we’ve got you covered.

In this IVY RX guide, we’ll walk you through 9 proven Wegovy alternatives that can help you lose weight in a healthy, sustainable way. Whether you prefer a generic GLP-1 or other medications that work in similar ways, we’ll show you what works.

Wegovy for Weight Loss: A Quick Overview

Wegovy (semaglutide) is a GLP-1 receptor agonist approved for chronic weight management. Semaglutide works by mimicking a hormone that reduces appetite and increases feelings of fullness, helping you eat less and lose weight.

Trials show it’s even more effective when you combine it with a reduced-calorie diet and increased activity. However, many people seek alternatives due to high costs, potential side effects, and the need for regular injections. 

Additionally, semaglutide supply shortages have made Wegovy harder to access, prompting users to look into other weight management options that suit their needs better.  

Popular Injectable Alternatives to Wegovy

There are a few effective and alternative options to explore, including Sermorelin, Lipotropic MIC B12, NAD+, Mounjaro, and Tirzepatide. 

Here’s how they compare, starting with Sermorelin. 

1. Sermorelin

Sermorelin is a synthetic peptide that stimulates the release of growth hormone from the pituitary gland. Unlike direct growth hormone therapy, it stimulates natural hormone production.  

Pros

• Enhances metabolism and fat breakdown: May help reduce stubborn fat, especially in areas like the abdomen.
• Supports lean muscle growth: Aids in building muscle mass, which helps with weight management.
• Improves sleep quality: Better sleep regulates hunger hormones and energy, aiding weight loss.
• Potential anti-aging benefits: Improves skin elasticity and overall vitality.

Cons

• Injection site reactions: Side effects may include irritation, itching, or swelling at the injection site.
• Possible allergic reactions: Some may experience dizziness, nausea, or a rash.
• Drug interactions: Can interact with thyroid medications, glucocorticoids, and insulin.
• Not suitable for everyone: Not recommended for pregnant women or those with certain health conditions.

Pricing

Pricing for Sermorelin injections can vary based on the sermorelin provider and additional services offered.

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Be sure to confirm the exact cost and any membership fees with each provider.

Who Sermorelin Is Best For

• Individuals seeking natural hormone stimulation: Those who prefer encouraging the body’s own growth hormone production.
• Adults experiencing age-related metabolic decline: Those noticing decreased metabolism, energy, or muscle mass with age.
• Those looking to improve body composition: Ideal for reducing fat and building lean muscle.
• People interested in anti-aging benefits: Those wanting to improve skin elasticity and overall vitality.

Start your journey to natural hormone support with IVY RX and access sermorelin injections today.

2. Lipotropic MIC B12 Injections

At-home lipotropic MIC B12 injections combine methionine, inositol, choline, and vitamin B12. These ingredients support fat metabolism, boost energy levels, and promote overall wellness.  

Pros

• Enhanced fat metabolism: Methionine, inositol, and choline aid in fat breakdown in the liver.
• Boosted energy levels: Vitamin B12 helps increase energy, potentially reducing fatigue.
• Improved liver function: Choline supports liver health, crucial for fat metabolism.
• Appetite regulation: Inositol may help balance neurotransmitters, potentially reducing cravings.

Cons

• Potential side effects: Side effects may include redness at the injection site, nausea, or fatigue.
• Not a standalone solution: These injections should complement diet and exercise for optimal results.

Pricing

Here’s a breakdown of the pricing for Lipotropic MIC B12 injections from various providers.

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Who This Alternative Is Best For

• Individuals seeking fat metabolism support: Those looking to enhance fat breakdown.
• People experiencing low energy levels: Ideal for those feeling fatigued and needing an energy boost.
• Individuals with liver health concerns: Supports healthy liver function.
• People struggling with appetite control: Helps manage cravings and appetite.

Ready to boost your metabolism and energy? Try Ivy’s Lipotropic MIC B12 injection now.

3. NAD+ Injections

Nicotinamide adenine dinucleotide (NAD+) supports cellular energy, DNA repair, and metabolism. Injecting NAD+ for supplementation can help restore vitality and support weight management as levels decline with age.

Pros

• Boosts metabolism: Enhances mitochondrial function, helping burn calories efficiently and aiding in weight loss.
• Increases energy levels: Combats fatigue, offering a natural energy boost.
• Supports cognitive function: Improves focus and mental clarity.
• Enhances cellular repair: Aids in DNA repair, promoting cellular health and longevity.

Cons

• Potential side effects: Some users may experience nausea, fatigue, or headaches after NAD+ injections.
• Cost: NAD+ therapy can be expensive, with prices varying based on dosage and provider.
• Limited availability: Not all healthcare providers offer NAD+ injections, requiring specialized clinics.

Pricing

NAD+ injection pricing differs across providers. 

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Who This Alternative Is Best For

• Individuals over 40: Ideal for those experiencing age-related metabolic slowdown.
• People seeking enhanced energy: Great for those dealing with chronic fatigue.
• Fitness enthusiasts: Athletes or active individuals looking to improve recovery and performance.
• Those interested in anti-aging: Supports cellular health and longevity for those looking to slow the aging process.

Ready to boost your energy and vitality? Try Ivy’s at-home NAD+ injections today and feel the difference. 

4. Tirzepatide

Tirzepatide (sold under the brand names Mounjaro or Zepbound), is a GLP-1 and GIP receptor agonist approved for type 2 diabetes, which shows significant weight loss when combined with diet and exercise.

Pros

• Significant weight loss: Up to 22.5% average body weight loss. When comparing tirzepatide and semaglutide (the active ingredient in Wegovy), tirzepatide results in 7.5% greater body weight loss.
• Improved insulin sensitivity: Enhances insulin secretion and reduces glucose production.
• Dual mechanism of action: Combines GLP-1 and GIP receptor agonism for better appetite suppression and fat breakdown.
• Additional health benefits: Users report improved sleep, energy, and libido.

Cons

• Potential side effects: Common tirzepatide side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain.
• Serious health risks: Boxed warning for thyroid cancer, pancreatitis, and kidney issues.
• Not FDA-approved for weight loss: Mounjaro is prescribed off-label for weight loss.
• Risk of disordered eating: Some may develop unhealthy eating behaviors or disorders when using Mounjaro.

Pricing

Here’s a pricing breakdown for Mounjaro. Prices may vary based on location and insurance.

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Who This Alternative Is Best For

• Individuals with obesity or overweight: BMI of 30+ or 27 with weight-related health issues.
• Patients with type 2 diabetes: Seeking better blood sugar control and weight management.
• People seeking significant weight loss: Struggling to reach goals with diet and exercise alone.
• Individuals under medical supervision: Able to commit to regular monitoring and follow-up care.

Looking to make the switch? For more affordable options without insurance coverage, see IvyRx’s personalized GLP-1 injections.

Non-Injectable Wegovy Alternatives

If you prefer non-injectable weight loss options, there are several alternatives to Wegovy. These options include oral medications and lifestyle changes. They can help manage weight effectively without the need for injections.

5. Metformin

Metformin, commonly used to manage type 2 diabetes, improves insulin sensitivity and reduces glucose production. It may also help with modest weight loss for weight management.

Pros

• Modest weight loss: Clinical studies show metformin can lead to a weight loss of 0.7 to 3.8 kg.
• Improved insulin sensitivity: Helps manage your blood sugar levels effectively.
• Low cost: Generic versions are affordable, starting at $5 for a 30-day supply.
• Additional health benefits: Offers cardiovascular benefits, reduces cancer risk, improves skin clarity, and helps manage PCOS symptoms.

Cons

• Gastrointestinal side effects: Common issues include diarrhea, nausea, and abdominal discomfort.
• Vitamin B12 deficiency: Long-term use can lower B12 levels.
• Risk of lactic acidosis: Rare, but possible, especially in individuals with kidney or liver problems.
• Not approved for weight loss: Metformin is not FDA-approved for weight loss, mainly used for managing type 2 diabetes.

Pricing

Here’s a pricing breakdown for Metformin. 

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Who This Alternative Is Best For

• Individuals with obesity or overweight: Those with a BMI of 30+ or 27+ with weight-related health issues.
• Patients with type 2 diabetes: Seeking better blood sugar control and weight management.
• People seeking weight loss: Those not achieving desired results with diet and exercise alone.

Try Metformin today for better blood sugar and weight management. Talk to your healthcare provider to get started. 

6. NAD+ Nasal Spray

NAD+ nasal spray is a simple, non-invasive way to boost your cellular energy, sharpen your focus, and support anti-aging. It helps replenish NAD+ levels, which naturally decline as we age.

Pros

• Increased energy: Boosts your NAD+ levels, helping you feel more energized and less fatigued.
• Cognitive support: Enhances your memory, focus, and mental clarity.
• Anti-aging benefits: Supports cellular repair and promotes longevity.
• Convenient: It’s easy to use with no needles, just a nasal spray.

Cons

• Nasal irritation: You may experience dryness or discomfort in your nose.
• Variable absorption: The effectiveness can vary from person to person.
• Mild side effects: Some users report headaches or nausea.
• Not FDA-approved: It isn’t regulated by the FDA for proven efficacy.

Pricing

Compare the cost of NAD+ nasal spray across providers.

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Who This Alternative Is Best For

• Cognitive enhancement: Perfect if you want to improve your mental clarity.
• Energy boost: Ideal if you’re struggling with fatigue and need more energy.
• Anti-aging: If you're looking to support your cellular health and fight aging.
• Non-invasive preference: Great for those who don’t want injections.

Before starting NAD+ nasal spray, talk to your healthcare provider to make sure it's right for you.

7. Glutathione

Glutathione is a powerful antioxidant that helps reduce oxidative stress, supports immune function, and promotes detoxification. It’s available in oral, subcutaneous injection or IV form, depending on your preference. 

Pros

• Antioxidant protection: It neutralizes free radicals. This, in turn, reduces oxidative stress and improves overall health.  
• Skin health: Glutathione brightens the skin tone and reduces dark spots.
• Detoxification: It aids in liver detoxification by helping your body eliminate toxins.
• Immune support: It enhances immune function, thus reducing the risk of infections.

Cons

• Gastrointestinal Issues: You might experience bloating, nausea, or diarrhea.
• Allergic Reactions: Rare itching or rash, especially with higher doses.
• Skin Lightening: May lighten your skin tone, which might not be desired.
• Not FDA-Approved for Weight Loss: Not officially approved for weight management.

Pricing

Here’s a breakdown of the pricing for Glutathione in various formulations:

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Who This Alternative Is Best For

• Skin care enthusiasts: Ideal for those wanting to brighten their skin and reduce the appearance of spots.
• Detox seekers: Great for anyone looking for liver support and detoxification.
• Fatigue sufferers: Perfect for those who need an energy boost and feel drained.
• Health-conscious individuals: Those looking for antioxidant protection and immune support.

Thinking about trying Glutathione? Talk to your healthcare provider to see if it’s right for you.

8. GLP-1 Boost

GLP-1 Boost supplements are natural alternatives to prescription GLP-1 medications. They are designed to help with appetite control, blood sugar regulation, and weight management.

Pros

• Appetite regulation: Some ingredients may have a modest effect on appetite hormones.
• Blood sugar support: Components like berberine have shown potential in lowering blood sugar levels.
• Convenience: Available over-the-counter, with no prescription needed.
• Natural ingredients: Formulated with plant-based extracts and fibers to support health.

Cons

• Mild effects: Benefits are generally modest, not comparable to prescription GLP-1 medications.
• Potential interactions: May interact with other medications, especially for those with diabetes.

Pricing

Here’s a breakdown of the pricing for GLP-1 Boost supplements, so you can easily compare options.

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Who This Alternative Is Best For

• Individuals seeking natural supplements: If you prefer plant-based options over pharmaceuticals, this is for you.
• People with mild appetite concerns: Suitable for those looking for modest appetite regulation.
• Budget-conscious consumers: Ideal for those seeking cost-effective alternatives to prescription medications.
• Health-conscious individuals: Best for those interested in supporting overall metabolic health naturally.

Interested in GLP-1 Boost? Talk to your healthcare provider to see if it’s the right option for you.

9. Orlistat (Alli / Xenical)

Orlistat is a weight-loss medication that reduces fat absorption in the body. Alli is the over-the-counter version, while Xenical requires a prescription.

Pros

• Fat absorption reduction: Blocks about 25% of dietary fat from being absorbed, supporting weight loss.
• Modest weight loss: Can help you lose a few more pounds than diet and exercise alone.
• Over-the-counter availability: No prescription needed for Alli, making it accessible.

Cons

• Gastrointestinal side effects: Can cause oily stools, frequent bowel movements, and abdominal discomfort.
• Limited effectiveness: Weight loss results are modest and vary from person to person.
• Nutrient absorption issues: May reduce absorption of fat-soluble vitamins like A, D, E, and K.

Pricing 

Here’s a pricing breakdown for Alli and Xenical, so you can compare options and find the best choice for your needs.

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Who This Alternative Is Best For

• Individuals seeking a non-prescription option: Ideal for those who prefer an over-the-counter medication.
• Those willing to manage side effects: Suitable for those who can tolerate gastrointestinal discomfort.
• People committed to a low-fat diet: Best for those who can stick to a low-fat diet for effectiveness.
• Not ideal for everyone: Always consult a healthcare provider before use.

Factors to Consider When Choosing a Wegovy Alternative

When choosing a Wegovy alternative, it's important to consider factors like how the medication is taken, potential side effects, cost, and convenience. These factors affect your treatment and results.

Administration Method

Wegovy is an injectable. If you’re not comfortable with injections, consider alternatives like oral medications or nasal sprays. GLP-1 supplements and oral metformin may be better options for you.

Side Effects

Common side effects include nausea, vomiting, diarrhea, and constipation. Some people also have abdominal pain or headaches. Think about how much you’re willing to tolerate before starting a treatment.

Cost and Insurance Coverage

Weight loss medications can be expensive. Wegovy, in particular, may cost a lot without insurance. Oral medications or supplements may be more affordable. Always check your insurance coverage and consider the cost of the treatment.

For more affordable options without insurance coverage, see IvyRx’s personalized GLP-1 injections.

Long-Term Commitment

Many weight loss medications need to be used long-term for lasting results. Think about your readiness for a long-term commitment and how this fits into your lifestyle.

Medical Supervision

Some treatments require ongoing medical supervision to manage progress and side effects. Be sure the alternative you choose provides enough support to keep you on track with your weight loss goals.

Accessing Wegovy Alternatives Through IVY RX

At IVY RX, we provide a wide range of Wegovy alternatives designed to support your weight loss and overall health goals. Whether you're interested in prescription medications, natural supplements, or telehealth consultations, we have options that can be customized to fit your unique needs.

Our alternatives include medications that target weight loss, metabolic health, and appetite control. Explore the available alternatives today and take the first step toward achieving your health goals. 

If you would like to switch to another GLP-1 medication, IvyRx offers consultations with affordable, personalized GLP-1 injections.

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